🧬 Multi-Edit CAR T-Cells: The Crazy Science That Might Cure Brain Cancer | Aaron Edwards (Part 4/4)
“This isn't just one gene edit—this is multiple edits, working in concert. It’s a fundamentally different chassis.”
In this episode of The Biotech Startups Podcast, Aaron Edwards, co-founder of KiraGen Bio, shares how a Harvard Business School class project ignited the launch of a pioneering biotech taking on solid tumors with a bold, unconventional CAR T-cell therapy.
He unpacks the real-world challenges of building KiraGen—navigating fundraising, assembling a strong team, and leveraging mentorship, partnerships, and machine learning—while highlighting how focus, discipline, and authentic leadership can set a startup apart, even when it means breaking from industry norms.
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“This isn't just one gene edit—this is multiple edits, working in concert. It’s a fundamentally different chassis.”
In this episode of The Biotech Startups Podcast, Aaron Edwards, co-founder of KiraGen Bio, shares how a Harvard Business School class project ignited the launch of a pioneering biotech taking on solid tumors with a bold, unconventional CAR T-cell therapy.
He unpacks the real-world challenges of building KiraGen—navigating fundraising, assembling a strong team, and leveraging mentorship, partnerships, and machine learning—while highlighting how focus, discipline, and authentic leadership can set a startup apart, even when it means breaking from industry norms.
Key topics covered:
- The Origin of KiraGen: Born from an HBS pitch deck, KiraGen set out to tackle immune suppression in solid tumors.
- Contrarian CAR T-Cell Design: Bold multi-edit strategy to outsmart tumor microenvironments and hit glioblastoma.
- Focus and Discipline: Lean operations, every dollar counts, eyes on clinical milestones.
- Creative Fundraising and Partnerships: Unconventional funding, academic alliances, and patient-driven capital.
- Authenticity and Team Building: Realness, inclusivity, and mentorship at the core—paying it forward in biotech.
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Intro & Outro Songs Created by OkKyojin, Owned by Excedr:
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Companies, Universities, & People mentioned:
Timestamps:
00:00 Intro
01:39 The Origin Story of KiraGen
07:15 From Bluebird to Beam: Learning Cell Therapy
15:51 Finding Product-Market Fit in Glioblastoma
20:59 The Importance of Focus and Discipline
24:20 Early Company Building and Lab Setup
28:16 Building the Team and Hiring Strategy
38:27 Creative Fundraising and Partnership Strategies
45:06 Two-Year Vision: IND Filing and Clinical Data
51:22 Shoutouts to Mentors and Supporters
55:50 Advice to 21-Year-Old Self: Authenticity as a Superpower
01:00:09 Outro