EP 165: Harnessing CRISPR and RNA editing to transform healthcare with Dr. Ness Bermingham
December 12, 2024
In this episode, we’re joined by Dr. Ness Bermingham, Operating Partner at Khosla Ventures and Chair of the Board at Korro Bio. A scientist-turned-biotech entrepreneur, Ness is passionate about the power of science to tackle some of healthcare’s biggest challenges.
Ness co-founded Intellia Therapeutics, a leader in CRISPR gene editing, and Korro Bio, an innovator in RNA editing, driving breakthroughs that translate cutting-edge science into real healthcare solutions. With over 20 years of experience in biotech and healthcare, he’s played a vital role in shaping startups into companies that develop life-changing medicines.
Tune in as we dive into Ness’s journey and his insights on innovation in biotech!
0:00 Introduction
1:29 Ness’ journey to becoming an entrepreneur and first-time founder.
5:37 Discussing CRISPR Therapeutics and its application in treating sickle cell disease.
7:43 Exploring the potential of RNA therapies and Ness’ work at Korro Bio.
11:29 Balancing scientific discovery with commercial viability in alpha-1 antitrypsin therapies for lung and liver diseases.
14:55 Creating a vision, setting realistic goals, and managing capital in early-stage biotech companies.
19:42 Differentiating biotech companies that use the same platform technologies, such as RNA editing.
24:19 Addressing regulatory barriers in drug development and exploring phenotypic manifestations of diseases.
28:53 Discussing bottlenecks in biotechnology, including drug delivery, regulation, patient segregation, and reimbursement.
33:02 Exploring how to price cures based on the financial burden saved by the healthcare system.
35:31 Sharing insights on Khosla Ventures’ investment in OpenAI and the impact of AI in biotech.
41:28 Discussing the role of AI in identifying drug targets, increasing impact rates, and enhancing patient safety.
46:23 Discovering what advancements in biotechnology Ness is most excited about.
51:40 Closing remarks.
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