EP 171: The past, present, and future of long-read sequencing with Jonathon Hill of Wasatch Biolabs
January 23, 2025
This week on The Genetics Podcast, Patrick is joined by Jonathon Hill, associate professor at Brigham Young University and co-founder and VP of Wasatch Biolabs. Jonathan and Patrick discuss the power of long-read sequencing, how Wasatch Biolabs was created, and how Jonathon has fostered valuable collaborations between academic labs and Wasatch Biolabs.
0:00 Intro to The Genetics Podcast
01:00 Welcome to Jonathon and background on the spin-out of Wasatch Biolabs
05:41 Limitations of short-read sequencing and advantages of long-read sequencing
09:16 The cost-benefit analysis of long-read sequencing across applications and objectives
13:03 How Jonathon became interested in nanopore sequencing
15:20 Detecting epigenetic signatures to diagnose, characterize, or predict various diseases
17:40 Proteomics applications, advantages, and disadvantages
20:08 The potential for long-read sequencing to become the diagnostic tool of choice
21:28 The synergy between Jonathon’s academic position at BYU and Wasatch Biolabs, and how the company was created
28:06 Utah as a biotechnology hub
28:55 The story behind the Wasatch Biolabs name
30:03 Jonathon’s excitement about AI and its potential for diagnostics
33:56 Closing remarks and ambitions for future data cohorts
Find out more
Wasatch Biolabs
https://www.wasatchbiolabs.com/
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