The Playbook To Building AI-Driven Innovation at Scale with Karen Pfeifer of Pythian
October 2, 2025
AI this, AI that - but how many of us are actually extracting its complete value and making it work for us? In this episode of Bringing Data and AI to Life, host and GVP Solutions Sales and Business Development at Informatica, Amy Horowitz sits down with Karen Pfeifer, Chief AI Officer at Pythian, to unravel the complexities of enterprise data and AI transformation. Drawing from her extensive experience at industry giants like Disney, Hulu, and Comcast, Karen shares invaluable insights on measuring data success through business impact, developing cross-functional teams, and navigating the challenges of AI governance. Her experiential perspectives offer practical wisdom on building trusted data foundations and embracing emerging trends like Agentic AI.
Tune in for a reminder that the bridge between technical innovation and tangible business outcomes exists, and you can cross it!
AI this, AI that - but how many of us are actually extracting its complete value and making it work for us? In this episode of Bringing Data and AI to Life, host and GVP Solutions Sales and Business Development at Informatica, Amy Horowitz sits down with Karen Pfeifer, Chief AI Officer at Pythian, to unravel the complexities of enterprise data and AI transformation.
What You’ll Learn
- How to transform raw data assets into strategic business drivers through a data-first, AI-centric approach
- The framework for measuring data success through concrete business metrics like cost reduction, customer retention, and revenue growth
- Why organizational culture and change management are crucial for successful AI implementation
- How to develop cross-functional data strategies that align with specific business outcomes
- The critical importance of building trusted data foundations before scaling AI initiatives
- How to navigate the balance between innovation and responsible AI usage in enterprise environments
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This podcast is brought to you by Informatica, the leader in enterprise cloud data management.
Links:
Karen Pfeifer on LinkedIn: https://www.linkedin.com/in/karen-pfeifer-data-strategy/
Pythian Website: https://www.pythian.com/
Amy Horowitz LinkedIn: https://www.linkedin.com/in/amyhorowitz
Informatica Website: https://www.informatica.com/
Data & AI Architecture Summit: https://now.informatica.com/ai-architecture-summit2025.html?Source=INFAPodcast
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Previous guests include:
Salema Rice host of Data Governance and Data Integration Solution Sales, Willem Koenders of ZS Associates, Tanja Ubert of Rotterdam University of Applied Sciences, Graeme Thompson of Informatica
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Bringing Data and AI to Life Guest and Audience Feedback
Leave us a voice note!
Previous guests include:
Salema Rice host of Data Governance and Data Integration Solution Sales, Willem Koenders of ZS Associates, Tanja Ubert of Rotterdam University of Applied Sciences, Graeme Thompson of Informatica
Check out our Top episodes:
- Why Do We Still Struggle to Trust AI? with Graeme Thompson from Informatica
- Data Quality Over Quantity and the Human Element, with Tanja Ubert from Rotterdam University
- The Power of Data Governance and Responsible AI with Salema Rice, Chief Executive Officer at CDO Today