EP 107: Integrating Genomics and Individualised Medicine into the Mayo Clinic Healthcare System with Dr. Konstantinos Lazaridis

In this episode of The Genetics Podcast, we welcome Dr. Konstantinos Lazaridis, the Executive Director of the Center for Individualized Medicine at the Mayo Clinic. Tune in to learn about the impacts of genomics and individualised medicine on rare liver diseases and advanced cancers . Discover how the Mayo Clinic actively uses genomic testing, precision medicine, and environmental interventions to improve patient outcomes.

Timestamps:

0:00 Introduction

0:32 Insights into the Center for Individualised Medicine at the Mayo Clinic, including the importance of predictive genomics, research in rare and undiagnosed diseases, and the integration of genomics into healthcare

4:40 Mayo Clinic’s Program for Rare and Undiagnosed Diseases (PRaUD): challenges faced and lessons learned

8:28 The Tapestry Study: integrating genomic data into patient care plans

11:40 The Tapestry Study: challenges in implementing healthcare interventions based on genetic findings

12:10 The Tapestry Study: The path to 100,000 whole exome sequences, including exciting findings, novel diagnoses, and future projections

13:20 The impact of the exposome (environmental exposures over the course of a lifetime) on genetic risk

16:45 Untapped data sources in exposome research

18:50 Linking the exposome to direct changes in cell physiology and metabolic pathways

21:34 Sources of exposome data - from blood draws to tissue samples

22:05 Painting a picture of the Center for Individualized Medicine in 20 years

23:30 Enhancing disease prevention, particularly for germline genetic diseases

26:38 Two scientists’ views on the humbling nature of biology

27:00 Mayo Clinic’s efforts to share its findings and precision medicine model with the world

28:10 Closing Remarks