EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University
July 4, 2024
This week, we welcome Lori Orlando, Associate Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University.
Lori discusses her work as a health services researcher, the MeTree family health history platform, and how she and her team are working to develop a sustainable model for bringing genomic medicine into primary care.
0:00 Intro to The Genetics Podcast
01:00 Welcome to Lori Orlando
03:00 Lori’s career: From mathematical modelling to genetics and family history
05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care
07:36 The first five diseases that Lori started analysing through informatics
09:56 The emergence of implementation science
11:47 Helping patients understand the implications and limitations of different types of genetic testing
13:11 The biggest challenges for the evolution of genomics and genetic testing
15:28 Emerging tools physicians can share to help patients understand genetic testing and its impacts
18:06 How primary care doctors can use genetic testing results to identify clear treatment pathways for specific conditions
24:33 The evolution of genetic counselling in primary care in the context of monogenic disease
28:34 Conditions where genetics, behaviour, and environment are deeply linked and where behaviour change can act as a preventative measure
35:00 Providing overall assessments to patients, including genetic testing and family history, to see how it changes their healthcare
35:50 How the MeTree platform is helping patients understand family health history
37:41 How to optimise family health history for current healthcare
42:15 Closing remarks
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